L-Threonine Side Effects
Foodchem International Corporation
L-Threonine, CAS# 72-19-5, is a amino acid manufactured through fermentation, available as White to light brown, crystal powder. L-Threonine is widely used as nutrition supplements. It is widely accepted as safe food additive in many countries.
Is there some safety and/or health risk about L-Threonine that consumers need to know? Let's check out some basic facts about this ingredient.
GRAS Exemptions: Yes
Foodchem Generally recognized as safe(GRAS) is a FDA designation that a specific substance or ingredient is generally considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. L-Threonine is perfectly safe for using as food additives.
As L-Threonine is widely known as safe, there is no limit on dosage of intake. However, we still recommend consumers to consult professionals before using large quantity of L-Threonine for long period.
Special Groups Precaution
Special groups refer to newborns, children, pregnant and any other applicable vulnerable groups.
There is no evidence that L-Threonine could have any negative effects on these vulnerable groups. It should be safe to use L-Threonine in food for newborns and pregnant. However, we still recommend consumers to consult professionals before using large quantity of L-Threonine for long period in food for newborns or pregnant.
General Side Effects
No significant side effects reported. L-Threonine can cause stomach upset, headache, nausea, and skin rash in specific groups of individuals.
Reported Health Issues
No health issues about L-Threonine reported up to now.
1. Spectral characterization of some second harmonic generation materials from the amino acid family: L-Threonine and L-prolinium tartrate. [Spectrochim Acta A Mol Biomol Spectrosc. 2014 Aug 14]
Author: Moovendaran K, Natarajan S.
2. Modification of glycolysis and its effect on the production of L-threonine in Escherichia coli. [J Ind Microbiol Biotechnol. 2014 Jun]
Author: Xie X, Liang Y, Liu H, Liu Y, Xu Q, Zhang C, Chen N.
3. Identification and characterization of protein encoded by orf382 as L-threonine dehydrogenase. [J Microbiol Biotechnol. 2014 Jun 28]
Author: Ma F, Wang T, Ma X, Wang P.
4. A QM/MM study of the L-threonine formation reaction of threonine synthase: implications into the mechanism of the reaction specificity. [J Am Chem Soc. 2014 Mar 26]
Author: Shoji M, Hanaoka K, Ujiie Y, Tanaka W, Kondo D, Umeda H, Kamoshida Y, Kayanuma M, Kamiya K, Shiraishi K, Machida Y, Murakawa T, Hayashi H.
5. Binding of NAD+ and L-threonine induces stepwise structural and flexibility changes in Cupriavidus necator L-threonine dehydrogenase. [J Biol Chem. 2014 Apr 11]
Author: Nakano S, Okazaki S, Tokiwa H, Asano Y.
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