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Melphalan is a bifunctional alkylating agent which is active against selective human euplastic diseases. Melphalan is a bifunctional alkylation agent. Formation of carboniumintermediates from each of the two bis-2-chloroethyl groups enables alkylationthrough covalent binding with the 7-nitrogen of guanine on DNA, cross-linking two DNA strands and thereby preventing cell replication.
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