Human Fas/TNFRSF6/CD95 ELISA Kit

Human Fas/TNFRSF6/CD95 ELISA Kit from Bio Ocean

By: Bio Ocean  11/19/2015
Keywords: Human Fas/TNFRSF6/CD95 ELISA Kit

Fas, also known as APO-1, or CD95, is a cell-surface receptor that transduces apoptotic signals from Fas ligand (FasL) .Fas forms the death-inducing signaling complex (DISC) upon ligand binding. Membrane-anchored Fas ligand trimer on the surface of an adjacent cell causes oligomerization of Fas. Recent studies which suggested the trimerization of Fas could not be validated. Other models suggested the oligomerization up to 5-7 Fas molecules in the DISC.Although Fas has been shown to promote tumor growth in the above mouse models, analysis of the human cancer genomics database revealed that FAS is not significantly focally amplified across a dataset of 3131 tumors (FAS is not an oncogene), but is significantly focally deleted across the entire dataset of these 3131 tumors, suggesting that FAS functions as a tumor suppressor in humans.In cultured cells, FasL induces various types of cancer cell apoptosis through the Fas receptor. In AOM-DSS-induced colon carcinoma and MCA-induced sarcoma mouse models, it has been shown that Fas acts as a tumor suppressor.Furthermore, the Fas receptor also mediates tumor-specific cytotoxic T lymphocyte (CTL) anti-tumor cytotoxicity. Serum Fas has been reported to be elevated in cancer patients, possibly originating in the tumor cell itself , and in autoimmune diseases.

Keywords: Human Fas/TNFRSF6/CD95 ELISA Kit

Other products and services from Bio Ocean

Human IFN-γ ELISA Kit from Bio Ocean thumbnail
11/19/2015

Human IFN-γ ELISA Kit

Interferon-gamma (IFN-γ) is a dimerized soluble cytokine that is the only member of the type II class of interferons. IFN-γ,


Human Granzyme K ELISA Kit from Bio Ocean thumbnail
11/19/2015

Human Granzyme K ELISA Kit

Granzymes are serine proteases that are released by cytoplasmic granules within cytotoxic T cells and natural killer cells. Their purpose


Human GM-CSF ELISA Kit from Bio Ocean thumbnail
11/19/2015

Human GM-CSF ELISA Kit

Granulocyte-macrophage colony stimulating factor (GM-CSF) is a cytokine that functions as a white blood cell growth factor. GM-CSF stimulates stem


Human Fas Ligand ELISA Kit from Bio Ocean thumbnail
11/19/2015

Human Fas Ligand ELISA Kit

Fas ligand (also known as TNFSF6, CD178, FasL or CD95L) is a type-II transmembrane protein that belongs to the tumor


Human CTGF ELISA Kit from Bio Ocean thumbnail
11/19/2015

Human CTGF ELISA Kit

Connective tissue growth factor (CTGF, CCN2) is a matricellular protein of the CCN family. has The extracellular part of CTGF


Human CRP ELISA Kit from Bio Ocean thumbnail
11/19/2015

Human CRP ELISA Kit

C-reactive protein (CRP) is an annular, pentameric protein. The physiological role of CRP is to bind to lysophosphatidylcholine expressed on


Human CCL4/MIP-1β ELISA Kit from Bio Ocean thumbnail
11/19/2015

Human CCL4/MIP-1β ELISA Kit

Macrophage Inflammatory Proteins (MIP) belong to the family of chemotactic cytokines known as chemokines. In humans, there are two major


Human CCL3/MIP-1α ELISA Kit from Bio Ocean thumbnail
11/19/2015

Human CCL3/MIP-1α ELISA Kit

Macrophage Inflammatory Proteins (MIP) belong to the family of chemotactic cytokines known as chemokines. In humans, there are two major


Human Adiponectin ELISA Kit from Bio Ocean thumbnail
11/19/2015

Human Adiponectin ELISA Kit

Adiponectin, also known as gelatin-binding protein of 28 kDa (GBP-28), adipose most abundant gene transcript 1 (apM1), Adipocyte complement-related protein